Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy
In summary, we identified TRAF7 as an essential regulator during cardiac hypertrophy, and modulation of the regulatory axis between TRAF7 and ASK1 could be a novel therapeutic strategy to prevent this pathological process.
Authors
- Hong-liang Qiu
- Manli Hu (ORCID: https://orcid.org/0000-0001-8318-0454)
- Zhaopeng Wang (ORCID: https://orcid.org/0009-0005-8257-0000)
- Hongxia Xia
- Yan Che (ORCID: https://orcid.org/0000-0002-4944-3860)
- Yi-Zhou Feng (ORCID: https://orcid.org/0000-0001-7049-1149)
- Qizhu Tang (ORCID: https://orcid.org/0000-0003-2210-3169)
- Yuan Yuan
- Yuting Liu (ORCID: https://orcid.org/0000-0001-8380-2882)
- Heng Zhou
- Shasha Wang
Institutions
- Wuhan University (CN)
- Gannan Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1093/cvr/cvae217
- Citations
- 8
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- National Science Foundation
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- National Health and Family Planning Commission of the People's Republic of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities