Phenotype remodelling of HNSCC cells in the muscle invasion environment
In this study, we profiled the transcriptional programs of muscle-invasive HNSCC cell populations and characterized their EMT and myoepithelial-like phenotypes. Furthermore, our findings highlight the presence of muscle-invasion as a predictive marker for HNSCC patients. G0S2 as one of the markers of muscle-invasive cancer cells is involved in HNSCC intravasation, probably via VEGF signalling.
Authors
- Huanzi Lu (ORCID: https://orcid.org/0000-0001-5243-9611)
- Guiqing Liao (ORCID: https://orcid.org/0009-0001-9411-1443)
- Jia‐shun Wu (ORCID: https://orcid.org/0000-0001-9554-1739)
- Wei Sun (ORCID: https://orcid.org/0000-0003-0299-8014)
- Yi Shen (ORCID: https://orcid.org/0009-0004-7758-6633)
- Yujie Liang
- Guozhong Zeng
Institutions
- Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s12967-024-05607-8
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province