Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models
NETs were significantly elevated during the perioperative period of cardiac surgery. Colchicine significantly mitigated myocardial injury in cardiac surgery by inhibiting NETs formation, with peptidylarginine deiminase 4 inhibition being one of its mechanisms.
Authors
- Xiaolu Jiao (ORCID: https://orcid.org/0000-0002-5619-0929)
- Yifan Zhu (ORCID: https://orcid.org/0000-0002-7695-1633)
- Chenyu Jiang (ORCID: https://orcid.org/0000-0003-2964-2309)
- Yu-Xian Tang
- Tuo Pan
- Wenxin Su (ORCID: https://orcid.org/0000-0002-5470-5853)
- Yusanjan Matniyaz (ORCID: https://orcid.org/0009-0002-2825-2368)
- Haitao Zhang (ORCID: https://orcid.org/0000-0002-3253-9727)
- Mingyue Liu (ORCID: https://orcid.org/0000-0002-4294-0389)
- Dongjin Wang (ORCID: https://orcid.org/0009-0000-3871-3100)
- Li Xu (ORCID: https://orcid.org/0000-0001-8872-342X)
- Zhi-Kang Lv
- Hao-Dong Pan
- You-Ru Kong
Institutions
- Nanjing University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Sir Run Run Shaw Hospital (CN)
- Shanghai Children's Medical Center (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Bethune Hospital of Jilin University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1093/ejcts/ezae364
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- Nanjing University