Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men
Low circulating SHBG is strongly associated with a low risk of fracture at all evaluated bone sites, while the associations of circulating T with fracture risk are of lesser magnitude, nonlinear, inconsistent among fracture site, and affected by adjustment for SHBG. These findings demonstrate that circulating SHBG, rather than T, is a major independent biomarker of fracture risk in men. Consequently, both total T and SHBG should be assessed when examining the relationship of endogenous T concentrations with fractures in middle-aged to older men.
Authors
- Louise Grahnemo (ORCID: https://orcid.org/0000-0001-5276-6612)
- Eric Orwoll (ORCID: https://orcid.org/0000-0002-8520-7355)
- Bu B. Yeap (ORCID: https://orcid.org/0000-0002-7612-5892)
- Alvin M. Matsumoto (ORCID: https://orcid.org/0000-0002-6506-8650)
- Dirk Vanderschueren (ORCID: https://orcid.org/0000-0003-1395-0104)
- Kevin Murray (ORCID: https://orcid.org/0000-0002-8856-6046)
- Maria Nethander (ORCID: https://orcid.org/0000-0003-3688-906X)
- Lauren T Tyack (ORCID: https://orcid.org/0009-0007-9326-2235)
- Ross J. Marriott (ORCID: https://orcid.org/0000-0002-8805-8498)
- Claes Ohlsson (ORCID: https://orcid.org/0000-0002-9633-2805)
Institutions
- University of Puget Sound (US)
- Oregon Health & Science University (US)
- The University of Western Australia (AU)
- University of Washington (US)
- Fiona Stanley Hospital (AU)
- Sahlgrenska University Hospital (SE)
- VA Puget Sound Health Care System (US)
- Region Västra Götaland (SE)
- Geriatric Research Education and Clinical Center (US)
- University of Gothenburg (SE)
- KU Leuven (BE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1210/clinem/dgae703
- Citations
- 7
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 2.50
Funders
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Novo Nordisk Fonden