Repeated radon exposure induced ATM kinase-mediated DNA damage response and protective autophagy in mice and human bronchial epithelial cells
The findings demonstrated that long-term exposure to radon gas induced DNA lesions in the form of DSBs and a series of ATM-dependent DDR pathways. Activation of the ATM-mediated autophagy may provide a protective and pro-survival effect on radon-induced DSBs.
Authors
- X.L. Wang (ORCID: https://orcid.org/0000-0002-9731-6890)
- Xiaoyu Chen (ORCID: https://orcid.org/0000-0002-1892-6237)
- Hailin Tian (ORCID: https://orcid.org/0000-0002-6891-7697)
- Lili Xin (ORCID: https://orcid.org/0000-0002-7266-9657)
- Jieyun Yin (ORCID: https://orcid.org/0000-0002-5265-3930)
- A N Wang
- Shan Shan
- Hong Chengjiao
- Jianmei Wan
- Cheng Tu
- Tong Jian
- Xiaohan Li
Institutions
- Soochow University (CN)
- Taiwan Centers for Disease Control (TW)
Publication Details
- Journal
- Toxicology Research
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1093/toxres/tfae165
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China