Possibilities of mitochondrial dysfunction diagnosis in chronic heart failure
The article presents preliminary study results of association of direct ultrastructural characteristics of mitochondria (MTC) in cardiomyocytes and indirect signs of mitochondrial dysfunction with clinical course and outcomes of chronic heart failure (CHF). According to electron microscopy of the myocardium a violation of the ultrastructure of MTC of cardiomyocytes is accompanied by a decrease in the rate of oxygen absorption by mitochondria of leukocytes of peripheral blood, separation of oxidation and phosphorylation processes, an increased rate of radiopharmaceuticals leaching from myocardium, indicating mitochondrial membrane damage, low tolerance to physical load and reduced oxygen consumption at peak of load test, which confirms the feasibility of studying associations of indirect signs of mitochondrial dysfunction with ultrastructural changes in the mitochondrial cardiomyocytes and clinical manifestations of heart failure.
Authors
- И. В. Степанов (ORCID: https://orcid.org/0000-0002-8543-6027)
- K. N. Vitt (ORCID: https://orcid.org/0000-0002-2629-6466)
- Ekaterina E. Syromyatnikova (ORCID: https://orcid.org/0009-0009-4372-4782)
- Olga V. Tukish (ORCID: https://orcid.org/0000-0002-7661-5808)
- М. О. Gulya (ORCID: https://orcid.org/0000-0001-5689-9754)
- В. А. Корепанов (ORCID: https://orcid.org/0000-0002-2818-1419)
- С. Л. Андреев (ORCID: https://orcid.org/0000-0003-4049-8715)
- Гарганеева Алла Анатольевна (ORCID: https://orcid.org/0000-0002-9488-6900)
- Э. Ф. Муслимова (ORCID: https://orcid.org/0000-0001-7361-2161)
- Кужелева Елена Андреевна (ORCID: https://orcid.org/0000-0002-8070-2234)
- S. A. Аfanasiev
- E. A. Vladimirova
Institutions
- Russian Academy of Sciences (RU)
- Siberian State Medical University (RU)
- Ministry of Health of the Russian Federation (RU)
- Tomsk National Research Medical Center (RU)
Publication Details
- Journal
- Siberian Journal of Clinical and Experimental Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.29001/2073-8552-2024-39-3-51-57
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.40