Elevated peripheral glutamate and upregulated expression of NMDA receptor NR1 subunit in insomnia disorder
Glutamatergic neurotransmission was abnormal in ID patients. Additionally, the mRNA expression levels of the NMDAR NR1 subunit appeared to have potential as a clinical biomarker for ID. However, the sample size of our study was limited, and future studies with larger sample sizes are needed to further validate and explore the mechanisms involved and to assess the reliability of the biomarker.
Authors
- Jiwu Liao (ORCID: https://orcid.org/0009-0009-6138-2712)
- Jiyang Pan (ORCID: https://orcid.org/0009-0008-3153-9187)
- Yixian Cai (ORCID: https://orcid.org/0000-0002-4443-6688)
- Xiaohui Hou (ORCID: https://orcid.org/0000-0001-6264-7051)
- Yaxi Liu (ORCID: https://orcid.org/0000-0002-3261-829X)
- Jingjing Lin (ORCID: https://orcid.org/0000-0002-1890-4871)
Institutions
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-10-07
- DOI
- https://doi.org/10.3389/fpsyt.2024.1436024
- Citations
- 5
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China