Single-cell RNA sequencing identifies a subtype of FN1 + tumor-associated macrophages associated with glioma recurrence and as a biomarker for immunotherapy
Our findings highlight a subtype of FN1 + TAMs associated with glioma recurrence, providing new insights into potential therapeutic targets. Moreover, the abundance of FN1 + TAMs hold promise for predicting immune therapy response and aiding in more precise risk stratification of recurrent glioma patients.
Authors
- Shan Jiang (ORCID: https://orcid.org/0000-0002-7733-4987)
- Houshi Xu (ORCID: https://orcid.org/0000-0002-2878-0913)
- Xiaoyu Liu (ORCID: https://orcid.org/0009-0002-3948-616X)
- Huihui Chai (ORCID: https://orcid.org/0000-0001-7292-8586)
- Junji Wei
- Jiawen Chen (ORCID: https://orcid.org/0000-0001-7101-3034)
- Ming Chen (ORCID: https://orcid.org/0000-0001-5041-9342)
- Zhifeng Shi (ORCID: https://orcid.org/0000-0003-1719-0456)
- Ruize Zhu
- Ying Mao
- Yue Wang (ORCID: https://orcid.org/0000-0002-4501-8699)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1186/s40364-024-00662-1
- Citations
- 16
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Peking Union Medical College Hospital
- National Key Research and Development Program of China