Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)
Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.
Authors
- Manon N.G.J.A. Braat (ORCID: https://orcid.org/0000-0001-6580-4331)
- Joyce M. van Dodewaard-de Jong (ORCID: https://orcid.org/0000-0003-2847-9060)
- Jacques Otten (ORCID: https://orcid.org/0000-0002-0491-8623)
- Gert J. Meijer (ORCID: https://orcid.org/0000-0001-7275-319X)
- Koen Zwart (ORCID: https://orcid.org/0000-0002-0369-4509)
- Cornelis J.A. Punt (ORCID: https://orcid.org/0000-0003-0846-1445)
- Guus Martinus Bol (ORCID: https://orcid.org/0000-0002-4021-3823)
- Jeanine M.L. Roodhart (ORCID: https://orcid.org/0000-0003-1398-8970)
- Remond J.A. Fijneman (ORCID: https://orcid.org/0000-0003-2076-5521)
- J.J.W. Lagendijk
- Anne M. May (ORCID: https://orcid.org/0000-0003-0643-3790)
- Tanja Oostergo (ORCID: https://orcid.org/0009-0004-8154-9069)
- M. Intven
- Frederieke H. van der Baan (ORCID: https://orcid.org/0000-0002-7421-6547)
- Dania Al‐Toma (ORCID: https://orcid.org/0000-0003-1266-6216)
- Maartje Los (ORCID: https://orcid.org/0000-0002-4953-5271)
- M. Koopman
Institutions
- Utrecht University (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- Diakonessenhuis hospital (NL)
- Meander Medisch Centrum (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2024-10-06
- DOI
- https://doi.org/10.1016/j.ctro.2024.100874
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00