Research progress on regulating mechanism of ferroptosis by traditional Chinese medicines for qi-invigoration and blood-activation

<p indent="0mm">Ferroptosis is an iron-dependent type of cell death, which mainly characterized by iron overload, lipid peroxidation and reactive oxygen species accumulation.In Chinese medicine “qi and blood” are an important part of the human body, as well as the power and source of life activities. Imbalance in “qi and blood” can lead to serious diseases, therefore, regulation of “qi and blood” serves as the fundamental principle and core concept in clinical disease treatment. Traditional Chinese medicine for qi-invigorating and blood-activating play an active role in regulating iron homeostasis and inhibiting ferroptosis, thereby contributing to the prevention and treatment of major diseases. This review not only summarize recent research progress in regulating ferroptosis-induced major diseases using traditional Chinese medicine, but also categorize existing traditional Chinese medicine interventions that invigorate qi and activate blood circulation, providing new insights for preventing and treating ferroptosis-induced major diseases.