The Relationship Between Anti–Cell Division Cycle and Apoptosis Regulator 1 Autoantibodies, Anti‐Sp4 Autoantibodies, and Cancer in Anti–Transcription Intermediary Factor 1γ–Positive Dermatomyositis
Both anti-Sp4 and anti-CCAR1 autoantibody subgroups are negatively associated with CAM. Although the magnitude of this association is substantial, cancer occasionally occurs in patients positive for either specificity. Conversely, approximately half of anti-TIF1γ-positive patients with DM are negative for both antibodies (anti-Sp4/anti-CCAR1 negative), and thus this subgroup may warrant more intensive cancer surveillance.
Authors
- Christopher A. Mecoli (ORCID: https://orcid.org/0000-0002-1429-8392)
- Livia Casciola‐Rosen (ORCID: https://orcid.org/0000-0002-4172-1539)
- Antony Rosen (ORCID: https://orcid.org/0000-0002-8374-4763)
- Andrew Lee Mammen (ORCID: https://orcid.org/0000-0003-3732-3252)
- Brittany L. Adler (ORCID: https://orcid.org/0000-0001-9912-2435)
- David Fiorentino (ORCID: https://orcid.org/0000-0001-7951-3674)
- Eleni Tiniakou (ORCID: https://orcid.org/0000-0003-4749-870X)
- Julie J. Paik (ORCID: https://orcid.org/0000-0001-8436-1601)
- Lisa Christopher‐Stine (ORCID: https://orcid.org/0000-0002-7150-7306)
- Jemima Albayda (ORCID: https://orcid.org/0000-0002-8030-9504)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- Stanford University (US)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2024-10-06
- DOI
- https://doi.org/10.1002/acr2.11750
- Citations
- 3
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Frank H. and Eva B. Buck Foundation
- Jerome L. Greene Foundation
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases