Plasma and CSF neurofilament light chain distinguish neurodegenerative from primary psychiatric conditions in a clinical setting
NfL levels were significantly higher in ND versus PPD. Plasma NfL showed strong diagnostic performance, comparable to CSF NfL, to distinguish ND from PPD. Diagnostic performance was higher in younger people, where diagnostic challenges are greater. Further research is needed on analytical and reference range factors, for clinical translation. These findings support a simple screening blood test for neurodegeneration.
Authors
- Qiao‐Xin Li (ORCID: https://orcid.org/0000-0001-8438-3763)
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Christiane Stehmann (ORCID: https://orcid.org/0000-0001-8282-9151)
- Burcu Sağlam
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Steven Collins (ORCID: https://orcid.org/0000-0002-5245-6611)
- Alexandra Waxmann
- Wendy Kelso (ORCID: https://orcid.org/0000-0001-5418-6080)
- Sarah Farrand (ORCID: https://orcid.org/0000-0003-0788-4112)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Christa Dang (ORCID: https://orcid.org/0000-0003-0905-282X)
- Samuel F. Berkovic (ORCID: https://orcid.org/0000-0003-4580-841X)
- Matthew Kang (ORCID: https://orcid.org/0000-0001-9375-3762)
- Thomas Borchard (ORCID: https://orcid.org/0000-0001-7876-0315)
- Dhamidhu Eratne (ORCID: https://orcid.org/0000-0002-3226-7645)
- Dennis Velakoulis (ORCID: https://orcid.org/0000-0002-8842-8479)
- Michael Keem (ORCID: https://orcid.org/0000-0002-3448-7350)
- Andrew Evans (ORCID: https://orcid.org/0000-0001-5519-981X)
- Richard Kanaan (ORCID: https://orcid.org/0000-0003-0992-1917)
- Mark Walterfang (ORCID: https://orcid.org/0000-0002-1389-3691)
- Kaj Blennow
- Amy Coe (ORCID: https://orcid.org/0000-0003-3723-7645)
- Keng Hong Chhoa (ORCID: https://orcid.org/0000-0001-7096-2617)
- Samantha M. Loi (ORCID: https://orcid.org/0000-0002-4953-4500)
- Alexander Santillo (ORCID: https://orcid.org/0000-0001-9717-0820)
- Courtney Lewis (ORCID: https://orcid.org/0000-0002-8902-445X)
- Jasleen Grewal (ORCID: https://orcid.org/0009-0003-8281-2597)
- Henrik Zetterberg
- Cath Kaylor‐Hughes
- Vladimir Marinov
Institutions
- University of Science and Technology of China (CN)
- The Royal Melbourne Hospital (AU)
- University of Wisconsin–Madison (US)
- Federation University (AU)
- The University of Melbourne (AU)
- Lund University (SE)
- Florey Institute of Neuroscience and Mental Health (AU)
- Austin Hospital (AU)
- Sarawak General Hospital (MY)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- National Ageing Research Institute (AU)
- Western Health (AU)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- Melbourne Health (AU)
- Alfred Health (AU)
- Austin Health (AU)
- University College London (GB)
- Monash University (AU)
- Australian Psychological Society (AU)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-06
- DOI
- https://doi.org/10.1002/alz.14278
- Citations
- 19
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 10.46
Funders
- Australian Government
- European Commission
- University of Melbourne
- Vetenskapsrådet
- HORIZON EUROPE Framework Programme
- Medical Research Council
- National Health and Medical Research Council