Association of genetic ancestry with pre-eclampsia in multi-ethnic cohorts of pregnant women
Self-reported maternal ethnicity is an imperfect proxy for genetically-computed individual ancestry estimates, particularly in ethnic minority groups. Genetically-computed African ancestry percentage was associated with early-onset pre-eclampsia independently of self-reported maternal ethnicity. Well-powered studies in multi-ethnic cohorts are required to delineate the genetic contribution to pre-eclampsia.
Authors
- Pirro G. Hysi (ORCID: https://orcid.org/0000-0001-5752-2510)
- Frances Conti‐Ramsden (ORCID: https://orcid.org/0000-0001-7081-6839)
- Lucy C. Chappell (ORCID: https://orcid.org/0000-0001-6219-3379)
- Dragana Vuckovic (ORCID: https://orcid.org/0000-0001-9343-6142)
- Jenny Myers (ORCID: https://orcid.org/0000-0003-0913-2096)
- Antonio de Marvao (ORCID: https://orcid.org/0000-0001-9095-5887)
- Carolyn Gill
- Abbas Dehghan (ORCID: https://orcid.org/0000-0001-6403-016X)
Institutions
- King's College London (GB)
- University of Manchester (GB)
- British Heart Foundation (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- UK Dementia Research Institute (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Pregnancy Hypertension
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.preghy.2024.101162
- Citations
- 6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Fetal Medicine Foundation
- Medical Research Council