ADIPOCINAS NA DIABETES MELLITUS GESTACIONAL

Gestational diabetes is a metabolic syndrome in which insulin-tolerant hormones are dysregulated during pregnancy. Pregnant women can develop type II diabetes mellitus (DM) 5 to 10 years after giving birth, which may or may not be treated. It is a metabolic disease characterized by high concentrations of glucose in the blood and is a major public health problem. The inability of tissues to absorb glucose for adequate use is known as insulin resistance, which is an extremely significant metabolic phenomenon in the pathophysiology of diabetes mellitus. It can be caused by a variety of factors. Hyperglycemia caused by this dysfunction can cause serious problems for the mother and baby, putting the pregnancy and the life of the couple at risk. Previously, adipose tissue was considered only an energy reservoir, but recently it was discovered that it can widely synthesize biologically active molecules known as adipokines. These molecules can participate in various metabolic and inflammatory reactions. The objective of this literature review is to present the most important adipokines that cause metabolic changes related to the development of gestational diabetes mellitus (GDM) and insulin resistance.