CCRR regulate MYZAP-PKP2-Nav1.5 signaling pathway in atrial fibrillation following myocardial infarction
Atrial fibrillation (AF) is the most common sustained arrhythmia which brings a heavy burden to the lives and health of patients worldwide. Our earlier research documented cardiac conduction regulatory RNA (CCRR) as an antiarrhythmic lncRNA in heart failure. Here, we report that CCRR was decreased in atrial tissue after MI, MYZAP, and Nav1.5 were increased in the atrium in cardiac-specific transgenic CCRR overexpression mice. Overexpression of CCRR carried by AAV-9 reversed the incidence and duration of AF and atrial conduction velocity in MI mice. MYZAP overexpression reversed the decreasing levels of PKP2, Nav1.5, and AF incidence after MI in addition to downregulating the expression levels of TLR2, TLR4, and inflammation-related factors following MI. Our work revealed that CCRR can improve the occurrence and development of AF after MI through the MYZAP-PKP2 pathway and inhibit Nav1.5 and TLR signaling pathways associated with inflammation, thus serving as a therapeutic target for AF.
Authors
- Siyun Li (ORCID: https://orcid.org/0000-0001-9850-0633)
- Lihua Sun (ORCID: https://orcid.org/0000-0002-7254-0474)
- Hua Yang (ORCID: https://orcid.org/0000-0002-6474-1065)
- Guangze Wang
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Huishan Luo
- Shengjie Wang (ORCID: https://orcid.org/0000-0001-8832-1965)
- Lina Xuan (ORCID: https://orcid.org/0000-0003-2127-592X)
- Qingqing Zhang (ORCID: https://orcid.org/0000-0001-6296-7522)
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-8951-7094)
- Baofeng Yang (ORCID: https://orcid.org/0000-0002-0125-1608)
- Jianjun Guo (ORCID: https://orcid.org/0000-0002-2162-4133)
- Feihan Sun
- Shijia Cui
- Xingmei Yang
Institutions
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Heilongjiang Academy of Sciences (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1016/j.isci.2024.111102
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Harbin Medical University
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province