Sivelestat Sodium Alleviates Ischemia-Reperfusion-Induced Acute Kidney Injury via Suppressing TLR4/Myd88/NF-κB Signaling Pathway in Mice
We demonstrated a previously unidentified mechanism that sivelestat effectively attenuates AKI-induced renal dysfunction, possibly through suppressing the TLR4/Myd88/ NF-κB pathway.
Authors
- Hailong Bing (ORCID: https://orcid.org/0000-0001-9032-4428)
- Qinjun Chu (ORCID: https://orcid.org/0000-0001-9210-5691)
- Meng Mao (ORCID: https://orcid.org/0000-0001-8537-6637)
- Xiaogao Jin (ORCID: https://orcid.org/0000-0001-7259-2541)
- Zhengyuan Xia (ORCID: https://orcid.org/0000-0002-7002-5524)
- Liwei Sun (ORCID: https://orcid.org/0000-0003-2926-8839)
- Yuanbo Wu (ORCID: https://orcid.org/0000-0002-5760-1718)
- Wangli Tian
- Jie Wang (ORCID: https://orcid.org/0000-0002-1200-1196)
- Wei Xu (ORCID: https://orcid.org/0009-0008-5887-7098)
Institutions
- Guangdong Medical College (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Zhengzhou Central Hospital (CN)
- Hubei Cancer Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/dddt.s480148
- Citations
- 5
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Science and Technology Department of Henan Province
- Henan Provincial Science and Technology Research Project