The first in‐human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT‐678 in acute coronary syndrome patients and healthy volunteers
These results suggest that DT-678 effectively overcomes clopidogrel HTPR resulting from genetic and/or clinical factors in Chinese ACS patients, demonstrating its potential to improve antiplatelet therapy.
Authors
- Yanjun Gong (ORCID: https://orcid.org/0000-0003-1281-1073)
- Fangfang Fan (ORCID: https://orcid.org/0000-0001-8351-4821)
- Xiying Chi (ORCID: https://orcid.org/0000-0003-2252-5994)
- Yinjuan Li
- Y. Eugene Chen (ORCID: https://orcid.org/0000-0003-2357-7825)
- Xinghe Wang (ORCID: https://orcid.org/0000-0002-4197-8545)
- Linzi Miao (ORCID: https://orcid.org/0000-0003-2935-3902)
- Daniel T. Eitzman (ORCID: https://orcid.org/0000-0002-6392-4871)
- Lin Qiu (ORCID: https://orcid.org/0000-0001-8419-1833)
- Shengcong Liu
- Yimeng Jiang (ORCID: https://orcid.org/0000-0003-2233-0775)
- Qiuping Shi (ORCID: https://orcid.org/0000-0002-1788-1241)
- Tieci Yi (ORCID: https://orcid.org/0000-0001-9080-7745)
- Pengkang He (ORCID: https://orcid.org/0000-0003-2680-8457)
- Caixia Yang
- Long Zhang (ORCID: https://orcid.org/0000-0002-7400-7737)
- Zhi Wang (ORCID: https://orcid.org/0000-0001-8315-3501)
- Bin Zhang (ORCID: https://orcid.org/0000-0003-4530-772X)
- Ting Wang (ORCID: https://orcid.org/0000-0002-6569-4395)
- Yuxi Li (ORCID: https://orcid.org/0000-0003-1556-598X)
- Yu Wang (ORCID: https://orcid.org/0000-0003-2989-4944)
- Fan Yang (ORCID: https://orcid.org/0000-0003-0165-9803)
- Haoming Zhang
- Yaxin Lou (ORCID: https://orcid.org/0000-0001-6383-246X)
- Yao Lu (ORCID: https://orcid.org/0000-0003-4180-194X)
- Haoyu Weng (ORCID: https://orcid.org/0009-0006-6318-5817)
- Mohetaboer Momin
- Chenxue Qu
- Ran You (ORCID: https://orcid.org/0000-0003-3852-5569)
- Yulong Xia (ORCID: https://orcid.org/0009-0002-9531-9374)
- Chunyu Han
- Jianping Li
- Zhihao Liu (ORCID: https://orcid.org/0009-0002-2665-3854)
- Jie Wang (ORCID: https://orcid.org/0000-0002-3879-0971)
- Chunyan Wang (ORCID: https://orcid.org/0000-0003-2854-1354)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- University of Michigan (US)
- Shaanxi Provincial People's Hospital (CN)
- Peking University First Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1111/bph.17355
- Citations
- 4
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Peking University