Pediatric Huntington Disease Brains Have Distinct Morphologic and Metabolic Traits: the <scp>RAREST</scp>‐<scp>JHD</scp> Study
POHD patients' brains exhibited distinct morphologic and metabolic traits compared to AOHD patients' brains, with longitudinal changes mirroring clinical progression. Hybrid FDG-PET/MRI highlighted a variable regional brain dysfunction in vivo, as a biological consequence of highly expanded CAG repeats. Findings provide further evidence that POHD is a distinct disease from AOHD.
Authors
- Ferdinando Squitieri (ORCID: https://orcid.org/0000-0002-7397-1727)
- Maria Eugenia Caligiuri (ORCID: https://orcid.org/0000-0002-2030-5552)
- Emanuele Tinelli (ORCID: https://orcid.org/0000-0002-3007-4022)
- Francesco Cicone (ORCID: https://orcid.org/0000-0003-4664-1965)
- Umberto Sabatini (ORCID: https://orcid.org/0000-0001-5321-8626)
- Giuseppe Lucio Cascini (ORCID: https://orcid.org/0000-0003-0332-2606)
- Giulia Giancaterino (ORCID: https://orcid.org/0009-0009-4575-7318)
- Patrizia Vizza (ORCID: https://orcid.org/0000-0002-0014-478X)
Institutions
- Casa Sollievo della Sofferenza (IT)
- Magna Graecia University (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1002/mdc3.14223
- Citations
- 3
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Ministero della Salute