Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium
Our preliminary findings support the hypothesis that fibrinogen enters the brain via blood-brain barrier disruption, promoting neuroinflammation and neuronal injury. However, we did not observe an association between cerebrospinal fluid fibrinogen and peak delirium severity in this limited cohort.
Authors
- David Kunkel (ORCID: https://orcid.org/0000-0003-1812-8312)
- Katerina Akassoglou (ORCID: https://orcid.org/0000-0002-2632-1465)
- Thomas Payne (ORCID: https://orcid.org/0000-0002-0383-4073)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Robert D. Sanders (ORCID: https://orcid.org/0000-0003-0113-0328)
- Niccolò Terrando (ORCID: https://orcid.org/0000-0003-1803-5853)
- Jennifer Taylor (ORCID: https://orcid.org/0000-0003-2152-4287)
- Richard Lennertz (ORCID: https://orcid.org/0000-0003-3273-9056)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Anke Meyer‐Franke
- Robert A. Pearce (ORCID: https://orcid.org/0000-0002-1516-6260)
- K. Konieczka
- Frankie Ingram
Institutions
- University of Science and Technology of China (CN)
- The University of Sydney (AU)
- Gladstone Institutes (US)
- University of Wisconsin–Madison (US)
- Duke University (US)
- University of California, San Francisco (US)
- Royal Prince Alfred Hospital (AU)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- Duke Medical Center (US)
- UK Dementia Research Institute (GB)
- Institut du Cerveau (FR)
- National Health and Medical Research Council (AU)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- BJA Open
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.bjao.2024.100349
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Alzheimer's Association
- Familjen Erling-Perssons Stiftelse
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Vetenskapsrådet
- UK Dementia Research Institute
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke