Environmental Cues Facilitate Maturation and Patterning of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Our data suggest that environmental cues related to the left ventricular ECM may promote differentiation to a more mature CM state compared to cells differentiated on a standard 2D monolayer, while facilitating organization into longitudinal micro-fibers. Our study highlights the utility of ECM as a differentiation substrate to promote CM maturation and fiber orientation <i>in vitro</i> .
Authors
- Alonzo D. Cook (ORCID: https://orcid.org/0000-0002-6032-4926)
- Enrique Coca
- Scott Cho (ORCID: https://orcid.org/0000-0002-7909-4702)
- Martin Tristani‐Firouzi (ORCID: https://orcid.org/0000-0001-5916-442X)
- Natalia S. Torres (ORCID: https://orcid.org/0000-0002-8192-2562)
- Christopher Kauffman (ORCID: https://orcid.org/0000-0003-1641-9714)
Institutions
- University of Utah (US)
- Sarepta Therapeutics (United States) (US)
Publication Details
- Journal
- Cellular Physiology and Biochemistry
- Published
- 2024-10-04
- DOI
- https://doi.org/10.33594/000000730
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Utah
- Nora Eccles Treadwell Foundation
- National Institutes of Health
- National Cancer Institute