Evaluation of Serum Ferritin, Iron and C-Reactive Protein Level in Children with Febrile Seizure in Wasit Province, Iraq

Background: Febrile seizures are a commonplace pediatric neurological sickness, often related to fever and infections. Recent research suggest a capability hyperlink among iron deficiency, inflammation, and the prevalence of febrile seizures, but the relationship remains underexplored in particular populations. This study aimed to assess the affiliation between serum iron, ferritin levels, and inflammatory markers (C-reactive protein [CRP] and white blood cell [WBC] remember) in youngsters with febrile seizures in comparison to healthful controls.Methods: A case-manage study become performed involving a hundred youngsters aged 6 months to 6 years, with 50 kids who skilled febrile seizures (patient institution) and 40 age-matched healthful controls. Serum ferritin, iron, CRP degrees, and WBC counts had been measured and compared between the 2 groups. The data have been analyzed the usage of impartial t-assessments, Pearson correlation, and multivariate logistic regression.Results: Children within the febrile seizure institution had extensively decrease serum ferritin (40.5 ± 30.2 ng/mL) and iron levels (40.8 ± 15.3 μg/dL) as compared to controls (85.7 ± 20.4 ng/mL and 75.4 ± 18.7 μg/dL, respectively; p < 0.001). CRP ranges and WBC counts had been notably better within the affected person organization (25.6 ± 48 mg/L and 18,400 ± 5,200 cells/μL, respectively) compared to controls (2.3 ± 1.1 mg/L and 7,200 ± 1,800 cells/μL; p < 0.001). A robust bad correlation was observed among CRP ranges with each serum ferritin (r = -0.462) and serum iron (r = -0.625). Multivariate logistic regression identified lower serum iron and ferritin stages, and better CRP and WBC counts as good sized unbiased predictors of febrile seizures.Conclusion: The findings advise that iron deficiency and accelerated inflammatory markers are tremendous chance factors for febrile seizures in kids. These effects highlight the importance of monitoring iron repute and managing inflammation in pediatric sufferers prone to febrile seizures.