The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre- and postsynaptic dynamics. Thereby, the SVC could be seen as an 'all-in-one' regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity.
Authors
- Stefan Jakobs (ORCID: https://orcid.org/0000-0002-8028-3121)
- Nadja A. Simeth (ORCID: https://orcid.org/0000-0001-8130-883X)
- Tim Salditt (ORCID: https://orcid.org/0000-0003-4636-0813)
- Marcus Müller (ORCID: https://orcid.org/0000-0002-7472-973X)
- Tiago F. Outeiro (ORCID: https://orcid.org/0000-0003-1679-1727)
- Oliver M. Schlüter (ORCID: https://orcid.org/0000-0001-8958-5815)
- Stefan Bonn (ORCID: https://orcid.org/0000-0003-4366-5662)
- Constantin Pape (ORCID: https://orcid.org/0000-0001-6562-7187)
- Stefan Klumpp (ORCID: https://orcid.org/0000-0003-0584-2146)
- Dragomir Milovanović (ORCID: https://orcid.org/0000-0002-6625-1879)
- Tatjana Tchumatchenko (ORCID: https://orcid.org/0000-0001-9137-809X)
- Svilen Veselinov Georgiev (ORCID: https://orcid.org/0000-0001-7978-8811)
- Peter Rehling (ORCID: https://orcid.org/0000-0001-5661-5272)
- André Fischer (ORCID: https://orcid.org/0000-0001-8546-1161)
- Noa Lipstein (ORCID: https://orcid.org/0000-0002-0755-5899)
- Sofiia Reshetniak (ORCID: https://orcid.org/0000-0003-4847-4144)
- Maksims Fiošins (ORCID: https://orcid.org/0000-0002-4966-2465)
- Victor Macarrón‐Palacios (ORCID: https://orcid.org/0000-0001-7788-4914)
- Benjamin H. Cooper (ORCID: https://orcid.org/0000-0003-2374-9922)
- Rubén Fernández‐Busnadiego (ORCID: https://orcid.org/0000-0002-8366-7622)
- Silvio O. Rizzoli (ORCID: https://orcid.org/0000-0002-1667-7839)
- Elisa D’Este (ORCID: https://orcid.org/0000-0003-0781-187X)
- Tobias Moser (ORCID: https://orcid.org/0000-0001-7145-0533)
- Marilyn Tirard (ORCID: https://orcid.org/0000-0002-5669-9610)
- Claudia Steinem (ORCID: https://orcid.org/0000-0001-8778-9283)
- Fred Wolf (ORCID: https://orcid.org/0000-0002-7068-3762)
- Viola Priesemann (ORCID: https://orcid.org/0000-0001-8905-5873)
- Felix Lange (ORCID: https://orcid.org/0000-0003-1135-0797)
- Christian Tetzlaff (ORCID: https://orcid.org/0000-0003-1901-6232)
- Nils Brose (ORCID: https://orcid.org/0000-0003-0938-8534)
- Henning Urlaub (ORCID: https://orcid.org/0000-0003-1837-5233)
- Carolin Wichmann (ORCID: https://orcid.org/0000-0001-8868-8716)
- Michael Fauth (ORCID: https://orcid.org/0000-0002-0732-2972)
- Felipe Opazo (ORCID: https://orcid.org/0000-0002-4968-9713)
- Cristian A. Bogaciu (ORCID: https://orcid.org/0009-0004-7781-7040)
- Sarah Köster
Institutions
- University of Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Max Planck Institute for Medical Research (DE)
- Max Planck Institute for Dynamics and Self-Organization (DE)
- Max Planck Institute for the Study of Religious and Ethnic Diversity (DE)
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
- Universitätsmedizin Göttingen (DE)
- European Neuroscience Institute Göttingen (DE)
- Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- The Journal of Physiology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1113/jp286400
- Citations
- 7
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Deutsche Forschungsgemeinschaft