Epigenome-Wide DNA Methylation in Unipolar Depression: Predictive Biomarker of Antidepressant Treatment Response?
The present results provide preliminary evidence for altered DNA methylation patterns to be associated with antidepressant treatment response in MDD. Provided significant replication in independent and larger samples, the present findings might in the future aid in clinical decision-making toward more individualized and thus more efficacious treatments of MDD.
Authors
- Katharina Domschke (ORCID: https://orcid.org/0000-0002-2550-9132)
- Miriam A. Schiele (ORCID: https://orcid.org/0000-0003-2613-6515)
- Pascal Schlosser (ORCID: https://orcid.org/0000-0002-8460-0462)
- Peter Zwanzger (ORCID: https://orcid.org/0000-0002-5385-8188)
- Jan Lipovsek
- Anna Köttgen (ORCID: https://orcid.org/0000-0002-4671-3714)
- Volker Arolt (ORCID: https://orcid.org/0000-0002-2445-9778)
- Kathrin Schwarte
- Óscar Crespo Salvador
- Bernhard T. Baune
Institutions
- Johns Hopkins University (US)
- University of Freiburg (DE)
- The University of Melbourne (AU)
- University of Münster (DE)
- Florey Institute of Neuroscience and Mental Health (AU)
- University Medical Center Freiburg (DE)
- Inn-Salzach-Klinikum (DE)
- German Centre for Cardiovascular Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1093/ijnp/pyae045
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Deutsche Forschungsgemeinschaft
- Doktor Robert Pfleger-Stiftung