Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches
These results indicate that application of metformin can alleviate oxidative stress and mitigate fibrosis in endometriosis lesions in a murine model of endometriosis, which highlights metformin's potential as a pharmacological intervention for improving infertility in endometriosis.
Authors
- Alexandra Gouveia (ORCID: https://orcid.org/0000-0001-8784-4246)
- Henrique Almeida (ORCID: https://orcid.org/0000-0002-3036-3211)
- Adriana R. Rodrigues (ORCID: https://orcid.org/0000-0002-9613-1552)
- João Tiago Guimarães (ORCID: https://orcid.org/0000-0003-4836-6311)
- Ana Catarina Neto (ORCID: https://orcid.org/0000-0002-5292-4390)
- Delminda Neves (ORCID: https://orcid.org/0000-0002-3301-8376)
- Sofia Lamas (ORCID: https://orcid.org/0000-0002-1665-1989)
- Maria Filomena Botelho (ORCID: https://orcid.org/0000-0001-7202-1650)
- Beatriz Araújo (ORCID: https://orcid.org/0000-0003-2181-2203)
Institutions
- Universidade do Porto (PT)
- Hospital de São João (PT)
- CUF Porto Hospital (PT)
- Hospital Braga (PT)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Clinical Academic Center of Braga (PT)
Publication Details
- Journal
- Reproductive BioMedicine Online
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.rbmo.2024.104474
- Citations
- 4
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Fundação para a Ciência e a Tecnologia