The intestinal microbiome, but not clinical aspects of inflammatory bowel disease, is impacted by lactose malabsorption compared to lactose digestion in children
LM does not affect the clinical presentation or outcomes of children with IBD. However, this study establishes that a single nonabsorbed fermentable food product can alter the IM in both a regional and disease-specific manner. As we continue to learn more about the pathophysiology of IBD and the role of the IM in disease onset and progression, it would be of benefit to examine the impact of other potential fermentable nutrients and their products on IBD outcomes.
Authors
- James Butcher (ORCID: https://orcid.org/0000-0002-7050-1834)
- David R. Mack (ORCID: https://orcid.org/0000-0001-5604-3200)
- Pauline Barbeau
- Alexandra Cohen (ORCID: https://orcid.org/0000-0001-9593-9093)
- Alain Stintzi (ORCID: https://orcid.org/0000-0003-3728-4038)
- Jennifer Li (ORCID: https://orcid.org/0000-0003-0186-8613)
- Ruth Singleton
Institutions
- University of Ottawa (CA)
- Agricultural Research Institute of Ontario (CA)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.ajcnut.2024.09.031
- Citations
- 1
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- University of Ottawa
- Genome Canada
- Ontario Genomics
- Government of Canada
- Ontario Genomics Institute
- Ontario Ministry of Economic Development and Innovation
- Crohn's and Colitis Canada
- Ministero dello Sviluppo Economico
- Canadian Institutes of Health Research