Progressive systemic inflammation precedes decompensation in compensated cirrhosis
Systemic inflammation drives cirrhosis progression during the decompensated stage, but its role in the compensated stage is unclear. We evaluated biomarkers of systemic inflammation, intestinal barrier integrity and bacterial translocation in patients with compensated cirrhosis and their dynamics in relation to the first decompensation. We demonstrate that low-grade inflammation and bacterial products are present in the systemic circulation in compensated cirrhosis, provided clinically significant portal hypertension has developed. We also show that worsening of systemic inflammation precedes the development of first clinical decompensation.
Authors
- Juan Carlos García‐Pagán (ORCID: https://orcid.org/0000-0001-9032-4954)
- L. Paule Peral (ORCID: https://orcid.org/0000-0003-1212-3270)
- Rafael Bañares (ORCID: https://orcid.org/0000-0002-0412-8437)
- Edilmar Alvarado‐Tápias (ORCID: https://orcid.org/0000-0003-2036-6133)
- José Luís Calleja (ORCID: https://orcid.org/0000-0002-2265-6591)
- Elisa Castillo (ORCID: https://orcid.org/0000-0003-0040-9757)
- Salvador Augustín (ORCID: https://orcid.org/0000-0002-3515-9033)
- Agustı́n Albillos (ORCID: https://orcid.org/0000-0001-9131-2592)
- Carles Aracil (ORCID: https://orcid.org/0000-0002-8228-9041)
- Joan Genescà (ORCID: https://orcid.org/0000-0002-0831-8422)
- Luís Téllez (ORCID: https://orcid.org/0000-0002-9254-3891)
- Càndid Villanueva (ORCID: https://orcid.org/0000-0002-3674-914X)
- Jackie Bosch (ORCID: https://orcid.org/0000-0001-6292-4207)
- Rubén Sánchez-Aldehuelo (ORCID: https://orcid.org/0000-0002-7597-5596)
- Juan G. Abraldeṣ (ORCID: https://orcid.org/0000-0003-3421-937X)
- Rosa Maria Morillas (ORCID: https://orcid.org/0000-0001-9117-5049)
- Beatriz Peñas (ORCID: https://orcid.org/0000-0001-5934-3524)
- María Poca (ORCID: https://orcid.org/0000-0002-0235-1395)
Institutions
- University of Bern (CH)
- Universidad Complutense de Madrid (ES)
- Universitat Autònoma de Barcelona (ES)
- University of Alberta (CA)
- Universidad de Alcalá (ES)
- University Hospital of Bern (CH)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Lleida (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Medical Research Network (US)
- Universidad Autónoma de Madrid (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101231
- Citations
- 6
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- Instituto de Salud Carlos III
- European Regional Development Fund