Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
CTGF plays a crucial role in the development of KBD. Curcumin has shown potential in inhibiting CTGF levels and reducing chondrocyte apoptosis, highlighting its promise as a therapeutic agent for preventing cartilage damage in KBD. Our findings provided valuable insights into the pathogenesis of KBD and could promote the development of novel therapeutic strategies for this debilitating disease.
Authors
- Yan Wen (ORCID: https://orcid.org/0000-0001-5317-4387)
- Dan He (ORCID: https://orcid.org/0000-0002-9544-5672)
- Shiqiang Cheng (ORCID: https://orcid.org/0000-0001-8427-0312)
- Xiaoge Chu (ORCID: https://orcid.org/0000-0003-2710-1429)
- Bolun Cheng (ORCID: https://orcid.org/0000-0003-2915-5535)
- Qingqing Cai (ORCID: https://orcid.org/0000-0001-5447-3282)
- Wenming Wei (ORCID: https://orcid.org/0000-0003-1125-2732)
- Sirong Shi (ORCID: https://orcid.org/0000-0002-4192-2613)
- Yumeng Jia (ORCID: https://orcid.org/0000-0003-0060-9257)
- Alexey A. Tinkov (ORCID: https://orcid.org/0000-0003-0348-6192)
- Xuena Yang (ORCID: https://orcid.org/0000-0001-7905-6901)
- Feng Zhang (ORCID: https://orcid.org/0000-0003-4556-8276)
- Chuyu Pan (ORCID: https://orcid.org/0000-0003-2836-0908)
- Anatoly V. Skalny (ORCID: https://orcid.org/0000-0001-7838-1366)
- Huan Liu (ORCID: https://orcid.org/0000-0002-2314-5136)
Institutions
- Sechenov University (RU)
- Yaroslavl State University (RU)
- National Health and Family Planning Commission (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.117148
- Citations
- 4
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Xi’an Jiaotong University
- Russian Science Foundation
- Natural Science Foundation of Shaanxi Province
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research