8177 Clinical Characteristics of Ketosis Prone Diabetes: Evaluating Diagnosis and Management Practices in a Real-Life Setting

Abstract Disclosure: Z. Tariq: None. A. Sinha: None. G. Shokry: None. K. Moors: None. S.S. Kodukula: None. Z.I. Saeed: None. Aims: While evidence supports the Aß (Auto-antibody status, Beta-cell function) classification of Ketosis Prone Diabetes (KPD), its implementation by healthcare providers (HCPs) remains unclear. We examined practices in managing KPD in a tertiary-care center and compared features between Aß subgroups. Methods: A retrospective longitudinal cohort study was conducted consisting of individuals aged 18 and above with diabetes who experienced diabetic ketoacidosis (DKA) between 2016 and 2021. Demographics, causes of DKA, auto-antibody status, beta-cell function, clinical characteristics, and follow-up care were assessed. Data were analyzed using descriptive and inferential statistics. Results: Among 1557 individuals with KPD, 11.6% underwent A testing, 20.2% underwent ß testing, and only 9.8% underwent both A and ß testing. HCPs were more likely to assess Aß status among those who were young, Black, and had new-onset diabetes (p<0.001). A-ß+ was the most common (53.9%), and A+ß+ was least common (5.9%) KPD. Clinical characteristics differed among subgroups, with ß- having a leaner BMI and more insulin dependence. Infection was the leading cause of DKA (37.9%), followed by unprovoked DKA (22.6%). Conclusion: Our study further validates and highlights the underutilization of Aß classification in KPD management and emphasizes the need for increased education among HCPs to improve care for people with KPD. Presentation: 6/1/2024