Oleanolic acid inhibits aldo-keto reductase family 1 member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines
Arecoline-induced ROS/RNS to hyper-activate AKR1B10 in tumor sphere cells via the TGF-β1-Smad3 pathway. Furthermore, AKR1B10 enhanced CDDP resistance in OSCC cells via EMT-inducing markers. Finally, Finally, OA may efficiently target CDDP resistance, reverse stemness in OSCC cells, and have the potential as a novel anticancer drug.
Authors
- Shih‐Jung Cheng (ORCID: https://orcid.org/0000-0003-4674-4892)
- Hsin‐Han Hou
- Wei‐Ting Kuo (ORCID: https://orcid.org/0000-0002-1230-0014)
- Han‐Yi Chou (ORCID: https://orcid.org/0000-0002-0643-0701)
- Mark Yen‐Ping Kuo (ORCID: https://orcid.org/0000-0001-8321-2575)
- Hui‐Hsin Ko (ORCID: https://orcid.org/0000-0002-2024-3865)
- Wei‐Wen Liu (ORCID: https://orcid.org/0000-0002-4608-1892)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.jds.2024.09.018
- Citations
- 2
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.65