Proteomic analysis and experimental validation reveal the blood–brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer’s disease
The effects of HSD on AD may be achieved by inhibiting the levels of fibrinogen and the interactions on glia cells in the brain, and by modulating the structure of intestinal microbiota and improving the blood-brain barrier function.
Authors
- Zijuan Zhang (ORCID: https://orcid.org/0000-0001-7047-4795)
- Zhenqiang Zhang (ORCID: https://orcid.org/0000-0002-1736-1289)
- Yunfang Su
- Junying Song (ORCID: https://orcid.org/0000-0002-9816-4454)
- Zhishen Xie (ORCID: https://orcid.org/0000-0002-0008-9637)
- Jiangyan Xu (ORCID: https://orcid.org/0000-0002-8723-1463)
- Huifen Ma (ORCID: https://orcid.org/0000-0001-5121-7566)
- Zhonghua Li (ORCID: https://orcid.org/0000-0003-0458-3664)
- Pan Wang (ORCID: https://orcid.org/0000-0002-5623-299X)
- Ningning Liu (ORCID: https://orcid.org/0000-0002-9587-2332)
- Ruiqin Sun
- Yiran Sun
- Jinlian Ma
- Congcong Shang
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1186/s13020-024-01016-7
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Natural Science Foundation of Henan Province