8050 Incidence And Geographic Distribution Of Pheochromocytoma And Paraganglioma In The Slovak Population

Abstract Disclosure: I. Jochmanova: None. M. Ircha: None. Pheochromocytoma (PHEO) and Paraganglioma (PGL) are neuroendocrine tumors originating from chromaffin tissues of the adrenal medulla or extra-adrenal paraganglia and are characterized by catecholamine overproduction. Excess of catecholamines and the risk of metastatic disease lead to increased morbidity and mortality as well as decreased quality of life of patients. While many studies focus on the etiopathogenesis, diagnosis, and treatment of these tumors, their epidemiology is not well known in many, especially small, countries. In our present study, we assessed the incidence of PHEO/PGL in Slovakia and compared it to other countries. Based on the acquired data, the incidence of PHEO/PGL in Slovakia is 0.13 cases per 100,000 inhabitants, while PHEO prevails (0.12 cases per 100,000 inhabitants). Within the Slovak Republic, we noted differences between the districts of the country. Compared to other countries, the overall incidence of PHEO/PGL in Slovakia seems to be slightly lower, however, this can also be the result of lower reporting of the cases into the national database. Presentation: 6/2/2024