8427 Association of Circulating Prolactin Levels with Degree of Glycemic Control as Determined by Glycated Hemoglobin

Abstract Disclosure: I.A. Hashim: None. E. Abraham: None. Background: Prolactin is suggested to stimulate pancreatic β cells and may thus play a role in glucose metabolism. This retrospective study examined the relationship between circulating prolactin levels and glycated hemoglobin (A1c) levels among diabetics and patients being investigated for glucose intolerance. Methods: A1c values and their corresponding prolactin levels performed over 15 months (July 2021 to October 2022) were retrieved from the electronic medical records and subjected to statistical analysis. Patients’ glycemic status was characterized as normal (A1c ≤5.7%), prediabetic or in control (A1c >5.7 to <6.4 %), diabetic in control (A1c >6.5% to <9.0%), and poorly controlled (A1c >9.0%). Results: A total of 276 patients were included in the study, ages ranged from 12 to 84 (median 37 years) among females (n=229) and from 14 to 75 (median 38 years) among male patients (n=47). In patients with A1c ≤5.7 (n=152, 55.1% of patients) A1c ranged from 4.1 to 5.6 (median 5.3%) and prolactin levels ranged from 14 to 84 (median 36 ng/dL). Patients with A1c levels >5.7 to <6.4 % (n=71, 25.7%) A1c ranged from 5.7 to 6.4 (median 5.9%) and prolactin levels ranged from 1 to 1152 (median 11.9 ng/dL). Patients with A1c levels >6.5 to <9.0 (n=33, 11.9%) A1c ranged from 6.6 to 9.0 (median 7.1%) and prolactin levels from 1.1 to 154.5 (median 11.9 ng/dL). Patients with A1c >9.0% (n=19, 6.9%) A1c ranged from 9.2 to 14.5 (median 10.5%) and prolactin levels ranged from 2.7 to 41.2 (median 14.6 ng/dL). Overall, there was no correlation between A1c and prolactin levels for all study patients (r = -0.03, p= 0.6). There was no significant difference in prolactin levels among patients with normal A1c and those in control (p= 0.57 and 0.33 respectively). However, prolactin levels were lower in patients with poor control (A1c >9%) (p=0.02).Discussion: Markedly elevated but not significantly different prolactin levels were observed in prediabetic patients and those with good control. However, significantly lower prolactin levels were observed in poorly controlled diabetic patients. The study findings suggest a possible role for prolactin in glycemic control and that further studies are required to further investigate pathophysiology and possible mechanism. Presentation: 6/2/2024