Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis
Our studies illuminate an unanticipated protective role of SMC-CCN2 against atherosclerosis. Disruption of vascular wall homeostasis resulting from vascular SMC CCN2 deficiency predisposes mice to atherosclerosis development and progression.
Authors
- Zuli Fu (ORCID: https://orcid.org/0000-0002-2445-7959)
- Ti Wang (ORCID: https://orcid.org/0000-0002-6828-7277)
- Chiyuan Zhang
- Qian Xu (ORCID: https://orcid.org/0000-0002-5223-9967)
- W. Robert Taylor (ORCID: https://orcid.org/0000-0002-5765-2419)
- Zhiyong Lin (ORCID: https://orcid.org/0000-0002-9663-3886)
- Claire M Holden (ORCID: https://orcid.org/0000-0003-3605-1136)
- Jisheng Sun (ORCID: https://orcid.org/0000-0003-0814-1118)
- Andrew Leask (ORCID: https://orcid.org/0000-0003-2832-283X)
- Jinhu Wang (ORCID: https://orcid.org/0000-0001-9477-0310)
- Ruizheng Shi
- Giji Joseph
- Hildebrando Candido Ferreira Neto
Institutions
- Central South University (CN)
- Emory University (US)
- Nantong University (CN)
- University of Saskatchewan (CA)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Xiangya Hospital Central South University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1093/cvr/cvae215
- Citations
- 6
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- American Heart Association
- National Institutes of Health