Inhibition of the FOXO1–ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control
Maintenance of MQC under chronic hypoxia is achieved through a series of injury-protection mechanisms, suggesting that FOXO1 inhibition may be crucial for future mitigation of chronic hypoxic cardiomyocyte injury in TOF.
Authors
- Jiangtao Dai (ORCID: https://orcid.org/0000-0002-6002-4456)
- Shulei Fan (ORCID: https://orcid.org/0000-0002-0865-5015)
- Chunnian Ren
- Linyun Xi
- Yonggang Li (ORCID: https://orcid.org/0000-0001-8974-3094)
- Quan Wang (ORCID: https://orcid.org/0000-0003-4886-402X)
- Zhengxia Pan (ORCID: https://orcid.org/0000-0001-9998-7391)
- Dawei He
- Hongbo Li
- Gang Wang (ORCID: https://orcid.org/0000-0001-9318-6251)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Population and Family Planning Science and Technology Research Institute (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1016/j.lfs.2024.123084
- Citations
- 8
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.87