8171 Analysis of Inflammatory Bowel Disease and Hashimoto's Disease: A Nationwide Study

Abstract Disclosure: C. Yang: None. L. Joo: None. B. Blair: None. Analysis of Inflammatory Bowel Disease and Hashimoto’s Disease: A Nationwide Study Introduction: The U.S. population is aging rapidly. There is limited data specifically for patients with Hashimoto’s disease who are older than or equal to 80 years old. We sought to examine the national inpatient sample database to describe in-hospital outcomes among these older patients. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with Hashimoto's disease using international classification of diseases 10th revision codes. We then examined the outcomes in patients who were older than or equal to 80 years old (YO) vs. younger than 80 years old. Linear regression and multivariate logistic was used accordingly to adjust for confounders. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay (LOS), and total hospital charges (TOTHCG). SPSS software was used for statistical analysis. Results: This study included 48,649 patients with Hashimoto’s disease, of which 3,038(6.2%) patients were over or equal to the age of 80. Admissions with Hashimoto’s and old age had higher prevalence of hypertension (12.3% Vs 11.3 %, p<0.001), diabetes mellitus (14.8% VS 11.4% p <0.001), and obesity (6.9% Vs 3.1%, p<0.001). In-hospital mortality was higher among the older cohort (2.6% Vs 0.87, p< 0.001). On linear regression analysis, increased age was associated with increased in-hospital mortality (p<0.001). On multivariable regression, age >80 years was associated with higher odds of inpatient mortality (OR1.229, CI 1.174-1.286, p<0.001)). It was also shown that older Hashimoto’s patients pay significantly more total hospital charges ($82,361vs $70,231) with higher length of stay (7.4 days vs 5.6 days, p<0.001). On secondary analysis, it has shown that Hashimoto’s patients aged more than or equal to 80 years old had higher odds of having Crohn’s Disease (OR 1.032, CI 1.014-1.049, p<0.001) and Ulcerative Colitis (OR 1.025, CI 0.991-1.061, p<0.001). Conclusion: In this nationally representative population-based retrospective cohort study, aging was associated with higher mortality and worse outcomes among patients with Hashimoto’s disease. These results were distinguished in patients with inflammatory bowel disease. Presentation: 6/2/2024