LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma
Collectively, our findings reveal, for the first time, that LINC01116 enhances Pol I transcription by scaffolding essential transcription factors to the ribosomal DNA promoter, thereby driving oncogenic activities in LUAD. We propose the c-Myc-LINC01116-Pol I axis as a critical oncogenic pathway and a potential therapeutic target for modulating Pol I transcription in LUAD.
Authors
- Srivatsava Naidu (ORCID: https://orcid.org/0000-0002-1441-2749)
- Sheetanshu Saproo (ORCID: https://orcid.org/0000-0002-2221-1840)
- Shashanka Shekhar Sarkar (ORCID: https://orcid.org/0000-0003-1639-2371)
- Mansi Sharma (ORCID: https://orcid.org/0000-0002-4026-5498)
Institutions
- Indian Institute of Technology Ropar (IN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1186/s12967-024-05715-5
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research