NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
Glioma-derived NPRL2/TRIM16/Gal-3 axis participates in the regulation of CD8<sup>+</sup>T cell cuproptosis, which provides a promising strategy to rescue the immune activity of CD8<sup>+</sup>T cells and reverse immunosuppression in glioma.
Authors
- Feng Wang (ORCID: https://orcid.org/0000-0002-4154-6507)
- Chen Jin (ORCID: https://orcid.org/0000-0001-6803-5785)
- Maoyuan Sun (ORCID: https://orcid.org/0009-0003-1247-182X)
- Yuan Cheng (ORCID: https://orcid.org/0000-0002-9763-7424)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-4582-2556)
- Maoxin Zhang (ORCID: https://orcid.org/0000-0002-6250-3610)
- Yuanyuan Wu (ORCID: https://orcid.org/0000-0001-6262-1513)
- Ning Huang (ORCID: https://orcid.org/0000-0002-0928-0091)
- Xu Luo
- Jianhe Yue
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1007/s00018-024-05454-2
- Citations
- 5
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Chongqing Postdoctoral Science Foundation
- Chongqing Medical University
- Centre Scientifique et Technique du Bâtiment
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission
- Chunhui Project Foundation of the Education Department of China