Oncolytic activity of a coxsackievirus B3 strain in patient-derived cervical squamous cell carcinoma organoids and synergistic effect with paclitaxel
CVB3/2035A showed oncolytic activity in CSCC cell lines, xenografts, and patient-derived tissue cultures and organoids. Furthermore, the virus exhibited synergistic anti-tumor effects with paclitaxel against CSCC. These results suggest CVB3/2035A could serve as an alternative or adjunct to current CSCC chemotherapy regimens.
Authors
- Nanyi Liu
- Yanzhen Lin (ORCID: https://orcid.org/0009-0002-5571-7757)
- Huan Zhao (ORCID: https://orcid.org/0000-0002-7859-3681)
- Ningshao Xia (ORCID: https://orcid.org/0000-0003-0179-5266)
- Changjian Fang
- Xiumin Huang (ORCID: https://orcid.org/0000-0001-8311-879X)
- Yu Kang (ORCID: https://orcid.org/0000-0001-5196-0376)
- Chuanlai Yang
- Haoyin Tan
- Tong Cheng (ORCID: https://orcid.org/0000-0002-1638-6214)
- Wei Wang (ORCID: https://orcid.org/0000-0003-1568-222X)
Institutions
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1186/s12985-024-02502-y
- Citations
- 4
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province