12619 Unraveling The Complexity Of Autoimmune Polyglandular Syndrome

Abstract Disclosure: U. Syed: None. N.E. Fretes Oviedo: None. Background: Autoimmune polyglandular syndromes (APS) are polyendocrinopathies characterized by autoimmune dysfunction of multiple endocrine organs. APS remains a challenging yet frequently undiagnosed entity in clinical practice, characterized by the coexistence of multiple autoimmune endocrine disorders. Clinical Case: Presented here is the case of a 37-year-old female initially diagnosed with T1DM at age thirteen, subsequently developing primary adrenal insufficiency in her 20s, along with Graves' disease managed with radioiodine ablation and later Hashimoto thyroiditis requiring levothyroxine therapy. The patient's clinical presentation underscores the challenge of managing hypoglycemic episodes in the setting of APS, where multiple autoimmune endocrine disorders converge. Additionally, gastrointestinal symptoms prompted screening for celiac disease, yielding negative results. Family screening revealed her daughter's diagnosis of diabetes mellitus, emphasizing the familial predisposition to autoimmune endocrine abnormalities. Conclusion: This case underscores the importance of comprehensive screening for APS in patients with T1DM, autoimmune thyroid disease, or adrenal insufficiency, as they may harbor multiple autoimmune conditions. Early recognition and management are imperative to mitigate the risk of complications. Furthermore, familial screening should be considered to identify at-risk relatives, facilitating early intervention, and reducing morbidity associated with APS. Presentation: 6/3/2024