Single-Hit and Multi-hit PIK3CA Short Variant Genomic Alterations in Clinically Advanced Prostate Cancer: A Genomic Landscape Study

Identification of multi-hit PIK3CA GA in CAPC highlights a potentially unique phenotype that may be associated with response to anti-PIK3CA targeted therapy and checkpoint inhibition, supporting relevant clinical trial designs.

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Publication Details

Journal
Targeted Oncology
Published
2024-10-05
DOI
https://doi.org/10.1007/s11523-024-01100-w
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
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Single-Hit and Multi-hit PIK3CA Short Variant Genomic Alterations in Clinically Advanced Prostate Cancer: A Genomic Landscape Study

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Single-Hit and Multi-hit PIK3CA Short Variant Genomic Alterations in Clinically Advanced Prostate Cancer: A Genomic Landscape Study

Michael F. Basin, Natalie Danziger, Gennady Bratslavsky, Smruthy Sivakumar, Ethan Sokol, Ryon P. Graf, Petros D. Grivas, Alina Basnet, Dean C. Pavlick, Philippe E. Spiess, Richard S.P. Huang, Carla M. Miguel, Douglas I. Lin, Joseph M Jacob, Andrea Necchi, Neil Vasan, Hanan Goldberg, Jeffrey S. Ross, Ashish M. Kamat, Liang Cheng
article en

Abstract

Identification of multi-hit PIK3CA GA in CAPC highlights a potentially unique phenotype that may be associated with response to anti-PIK3CA targeted therapy and checkpoint inhibition, supporting relevant clinical trial designs.

Targeted OncologyVol. 19(6)
The University of Texas MD Anderson Cancer Center (US), Vita-Salute San Raffaele University (IT), University of Washington (US), SUNY Upstate Medical University (US), Brown University (US), Moffitt Cancer Center (US), Fred Hutch Cancer Center (US), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), Foundation Medicine (United States), Columbia University (US)
Openalex Percentile: Top 68%
Prostate Cancer Treatment and Research
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