Single-Hit and Multi-hit PIK3CA Short Variant Genomic Alterations in Clinically Advanced Prostate Cancer: A Genomic Landscape Study
Identification of multi-hit PIK3CA GA in CAPC highlights a potentially unique phenotype that may be associated with response to anti-PIK3CA targeted therapy and checkpoint inhibition, supporting relevant clinical trial designs.
Authors
- Michael F. Basin (ORCID: https://orcid.org/0000-0002-2905-0824)
- Natalie Danziger (ORCID: https://orcid.org/0000-0003-2642-7160)
- Gennady Bratslavsky (ORCID: https://orcid.org/0000-0002-2712-4375)
- Smruthy Sivakumar (ORCID: https://orcid.org/0000-0001-7790-5615)
- Ethan Sokol (ORCID: https://orcid.org/0000-0002-5480-8473)
- Ryon P. Graf (ORCID: https://orcid.org/0000-0002-8065-4148)
- Petros D. Grivas (ORCID: https://orcid.org/0000-0003-3965-3394)
- Alina Basnet (ORCID: https://orcid.org/0000-0002-6033-6943)
- Dean C. Pavlick (ORCID: https://orcid.org/0000-0001-6075-6246)
- Philippe E. Spiess (ORCID: https://orcid.org/0000-0002-5723-1972)
- Richard S.P. Huang (ORCID: https://orcid.org/0000-0001-8395-5168)
- Carla M. Miguel (ORCID: https://orcid.org/0000-0003-1352-0614)
- Douglas I. Lin (ORCID: https://orcid.org/0000-0003-0105-9760)
- Joseph M Jacob (ORCID: https://orcid.org/0000-0001-8769-2086)
- Andrea Necchi (ORCID: https://orcid.org/0000-0002-3007-2756)
- Neil Vasan (ORCID: https://orcid.org/0000-0003-1779-484X)
- Hanan Goldberg (ORCID: https://orcid.org/0000-0002-5777-2138)
- Jeffrey S. Ross (ORCID: https://orcid.org/0000-0001-8494-2596)
- Ashish M. Kamat
- Liang Cheng (ORCID: https://orcid.org/0000-0003-4288-1486)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Vita-Salute San Raffaele University (IT)
- University of Washington (US)
- SUNY Upstate Medical University (US)
- Brown University (US)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Foundation Medicine (United States)
- Columbia University (US)
Publication Details
- Journal
- Targeted Oncology
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1007/s11523-024-01100-w
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00