7088 Serum PFAS Concentrations And Lipid Health In Adolescents : A Cross-Sectional Study From Korean National Environmental Health Survey 2018-2020

Abstract Disclosure: M. Shin: None. S. Kim: None. Backgrounds: Perfluoroalkyl substances (PFAS), widespread environmental contaminants, have been implicated in dyslipidemia in adults, but their impact on adolescent lipid profiles remains unclear. This study examines the association between serum PFAS concentrations and subnormal lipid profiles in a representative sample of Korean adolescents. Methods: Utilizing data from the fourth cycle of the Korean National Environmental Health Survey (2018-2020), we conducted a cross-sectional analysis on adolescents aged 12-17 (N=818). Serum PFAS concentrations—specifically PFOS, PFOA, PFHxS, PFNA, and PFDeA—were stratified into tertiles. Adjusted percentage changes in lipid parameters and the odds of suboptimal lipid profiles were calculated using multivariable linear and logistic regression models, adjusting for potential confounders. Results: Higher PFAS concentrations, particularly in the top tertile, were significantly associated with altered lipid profiles. Increased PFOS in the upper tertile corresponded with raised HDL-cholesterol levels, while PFNA and PFDeA showed similar associations with LDL-cholesterol and non-HDL-cholesterol. The logistic regression analysis showed that for PFNA, adolescents in the highest tertile had increased odds of an elevated LDL- cholesterol (OR: 2.24; 95% CI: 1.12-4.48), and PFDeA was associated with an increased total cholesterol (OR: 1.80; 95% CI: 1.21-2.66) when compared to the lowest tertile. Other PFAS compounds did not demonstrate a consistent pattern of significant associations with lipid parameters. Conclusions: These results underscore the possible health consequences of PFAS exposure and the risk of dyslipidemia among adolescents. Additional studies are required to confirm these links and to understand the underlying mechanisms involved. Presentation: 6/1/2024