8771 Evolving Landscape of Thyroid Cancer Attributable to High Body Mass Index in 38 OECD Countries (1990-2019): A Comprehensive Global Assessment

Abstract Disclosure: V. Adedara: None. M. Chinthapalli: None. A. Parisapogu: None. G. Potluri: None. K. Markandu: None. K. Maddineni: None. H. Desai: None. Introduction: Thyroid cancer (TC) is an increasingly pressing health issue worldwide, particularly within the Organisation for Economic Co-operation and Development (OECD) countries, which account for 36.57% of all global TC cases. This study focuses on the impact of high Body Mass Index (h-BMI), paralleling rising obesity rates, on the burden of TC across 38 OECD countries. Method: Employing the Global Burden of Disease framework, we analyzed the trends in deaths, Disability Adjusted Life Years (DALYs), and Years Lived with Disabilities (YLDs) attributable to TC attributable to h-BMI, considering variables such as age, sex, year, and location over the past three decades. Results: Our findings show a significant increase in the total number of TC deaths attributable to h-BMI, rising from 873 (95%UI: 422-1471) in 1990 to 1646 (95%UI: 819-2703) in 2019. Similarly, DALYs escalated from 22041 (95%UI: 10576-37075) in 1990 to 39485 (95%UI: 19952-63534) in 2019, with YLDs increasing from 2360 (95%UI: 1082-4179) to 6170 (95%UI: 3036-10416). The age-standardized rate (ASR) showed an annual percentage change (APC) in the death rate of 5% (95%UI: -0.07-20%), and a 10% increase (95%UI: 2-10) in DALYs rate over three decades. The United States reported the highest number of deaths at 449 (95%UI: 233-703) in 2019. Regarding ASR, Iceland had the highest death rate of 0.16 per 100,000, followed by Mexico (0.13), Estonia (0.11), and Latvia (0.11). Males exhibited a higher APC in deaths (131% vs. 60%) and DALYs (112% vs. 52%) compared to females over the last three decades. Additionally, an increase in deaths was observed with advancing age, with the highest DALYs noted in the 75-79 year age group. Conclusion: To effectively address the rising thyroid cancer rates linked to high BMI, a unified approach is essential: public health policies must focus on obesity prevention, clinicians should integrate BMI management in thyroid cancer care, collaboration between policymakers and healthcare providers needs strengthening, and public awareness about the risks of high BMI must be increased to promote early screening and lifestyle changes. Presentation: 6/3/2024