Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy
Neuronal hypofunction in awake and behaving mice in early stages of tauopathy. Altered network activity disrupted local circuitry engagement in tauopathy mice. Enhanced neuronal excitability and altered synaptic transmission in tauopathy mice. Tau antibody acutely reduced soluble phospho-tau and improved neuronal function.
Authors
- Yanmei Zhou (ORCID: https://orcid.org/0000-0001-8203-245X)
- Qian Wu (ORCID: https://orcid.org/0000-0002-8912-0118)
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0002-7847-0665)
- Alejandro Martín‐Ávila (ORCID: https://orcid.org/0000-0003-0343-1685)
- Wen‐Biao Gan
- Amber M. Tetlow
- Einar M. Sigurdsson (ORCID: https://orcid.org/0000-0003-1451-0952)
- Soomin C. Song (ORCID: https://orcid.org/0000-0002-9581-0991)
- Changyi Ji (ORCID: https://orcid.org/0000-0002-0846-7954)
- Mohamed Eleish
- Yan Lin (ORCID: https://orcid.org/0009-0005-9357-4832)
- Yixiang Jiang (ORCID: https://orcid.org/0009-0008-3218-3071)
Institutions
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1002/alz.14273
- Citations
- 2
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Alzheimer's Association
- York University
- National Institutes of Health