Development of a new paradigm model for deciphering action mechanism of Danhong injection using a combination of isothermal shift assay and database interrogation
Overall, we established a novel paradigm model for the identification of targets and their respective ingredients in DHI, which facilitates the discovery of drug candidates and targets for improving disease management and contributes to revealing the underlying mechanisms of TCM and fostering TCM development and modernization.
Authors
- Tianxiang Wang
- Ke Wen (ORCID: https://orcid.org/0000-0002-2080-6541)
- Xianbin Meng (ORCID: https://orcid.org/0000-0002-5499-9433)
- Haiteng Deng (ORCID: https://orcid.org/0000-0001-9496-1280)
- Songbiao Zhu (ORCID: https://orcid.org/0000-0001-9383-2102)
- Yujiao Zhao
- Changmei Yang (ORCID: https://orcid.org/0000-0003-4961-6773)
- Wei Wei (ORCID: https://orcid.org/0000-0003-3561-913X)
- Yuling Chen (ORCID: https://orcid.org/0000-0001-5110-1096)
- Zhiqiang Li (ORCID: https://orcid.org/0009-0002-9168-5174)
- Sijing Du
- Yuxiang Tang
- Yuxin Ma
- Zelong Miao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- China Academy of Chinese Medical Sciences (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1186/s13020-024-01017-6
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China
- Tsinghua University
- National Key Research and Development Program of China