Exploring the septum pellucidum: Short review of anatomical insights and the clinical impact of septum pellucidum and cavum septi pellucidi

The septum pellucidum (SP) is a thin, triangular, and delicate structure in the brain. It consists of two layers of white and gray matter and topographically is located between the lateral ventricles. The SP is part of the limbic system, which involves emotions, behavior, and memory. This concise review provides an overview of the anatomy, development, and clinical significance of the SP, with a specific focus on cavum septi pellucidi (CSP). It also discusses its implications for brain function and its potential link to neurological disorders. As an essential structure within the limbic system, the SP and its associated variations, like CSP, offer valuable insights into brain development and function, particularly concerning emotions, memory, and psychiatric disorders. Understanding the role of the septum pellucidum and its developmental anomalies may shed light on various neuropsychiatric conditions and help guide future research and clinical practices. • This report presents the meaning of septum pellucidum and its anatomical variation – cavum septi pellucidi. • The septum pellucidum is part of the limbic system, which is involved in emotions, behavior, and memory. • An overview of the anatomy, development, and clinical significance of the septum pellucidum is provided. • The review discusses implications of septum pellucidum for brain function and its potential link to neurological disorders.