DGE-ontology: A quick and simple gene set enrichment analysis and visualisation tool

High-throughput quantification techniques provide considerable amounts of data. Making sense of such data requires not only thorough statistical analysis but a logical approach to data visualisation. DGE-ontology is software that has been primarily designed for transcriptomics, however it may be utilised for any data that express fold change of relative or absolute quantity measures of multiple entities, such as transcripts, proteins or metabolites. The software integrates results of differential and functional analyses in order to produce a single circular, highly informative and visually appealing chart. The chart simultaneously depicts numbers of quantified entities, their assignment to functional categories, singles out statistically over-represented categories, and visualises quantity fold change values. The presented approach to data visualisation considerably facilitates communication of experimental results as well as inference from large omic data sets.

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Publication Details

Journal
SoftwareX
Published
2024-10-04
DOI
https://doi.org/10.1016/j.softx.2024.101899
Primary Topic
Bioinformatics and Genomic Networks
Type
article
Field-Weighted Citation Impact
0.00

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article

DGE-ontology: A quick and simple gene set enrichment analysis and visualisation tool

Michał Bukowski, Benedykt Władyka
SoftwareX
Bioinformatics and Genomic Networks
article

DGE-ontology: A quick and simple gene set enrichment analysis and visualisation tool

Michał Bukowski, Benedykt Władyka
article en

Abstract

High-throughput quantification techniques provide considerable amounts of data. Making sense of such data requires not only thorough statistical analysis but a logical approach to data visualisation. DGE-ontology is software that has been primarily designed for transcriptomics, however it may be utilised for any data that express fold change of relative or absolute quantity measures of multiple entities, such as transcripts, proteins or metabolites. The software integrates results of differential and functional analyses in order to produce a single circular, highly informative and visually appealing chart. The chart simultaneously depicts numbers of quantified entities, their assignment to functional categories, singles out statistically over-represented categories, and visualises quantity fold change values. The presented approach to data visualisation considerably facilitates communication of experimental results as well as inference from large omic data sets.

SoftwareXVol. 28
Jagiellonian University (PL)
Narodowe Centrum Nauki
Openalex Percentile: Top 84%
Bioinformatics and Genomic Networks
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DGE-ontology: A quick and simple gene set enrichment analysis and visualisation tool — Michał Bukowski, Benedykt Władyka · SoftwareX (2024) | TGRS Research Map | TGRS