Integrative Management of Bone Deformities in Osteogenesis Imperfecta: A Case Report on Zoledronic Acid and Corrective Osteotomy

Osteogenesis imperfecta (OI) is a hereditary genetic condition characterized by brittle bones that are easily broken. Surgical intervention is necessary frequently to treat fractures and deformities in patients diagnosed with OI. In this case, we discuss a case of a nine-year-old male child diagnosed with OI. This boy was previously operated on one year back for a femur fracture with osteotomy and internal fixation with nails, followed by implant removal at a later stage almost one year later. This boy was brought to our hospital with convex deformities of femur and tibia. Upon evaluation and review of this boy's case, the decision was made to administer a zoledronic acid infusion cycle over three days to enhance bone strength. Following this pharmacological therapy, this patient was planned for corrective osteotomy and internal fixation of the femur. This case underscores the complexities of managing OI and also highlights the importance of the therapeutic role of bisphosphonates like zoledronic acid alongside surgical intervention to address these kinds of bony deformities and improve patient outcomes.