CRISPR-mediated WNK4 point mutation aggravates tumor progression and weakens chemotherapy sensitivity in gastric cancer.

Through activating STAT3, WNK4 mutation impacts both the natural and drug-treated growth of GC cells or tumors, suggesting a new avenue for preclinical research.

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Publication Details

Journal
PubMed
Published
2025-05-01
DOI
https://doi.org/10.14670/hh-18-810
Primary Topic
CRISPR and Genetic Engineering
Type
article
Field-Weighted Citation Impact
0.00
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article

CRISPR-mediated WNK4 point mutation aggravates tumor progression and weakens chemotherapy sensitivity in gastric cancer.

Xiao‐Bing Gao, Xinting Lv, Yong Wang, Xiaojun Ying et al.
PubMed
CRISPR and Genetic Engineering
article

CRISPR-mediated WNK4 point mutation aggravates tumor progression and weakens chemotherapy sensitivity in gastric cancer.

Xiao‐Bing Gao, Xinting Lv, Yong Wang, Xiaojun Ying, Zhen Ying
article en

Abstract

Through activating STAT3, WNK4 mutation impacts both the natural and drug-treated growth of GC cells or tumors, suggesting a new avenue for preclinical research.

PubMedVol. 40(5)
Sir Run Run Shaw Hospital (CN), Zhejiang University (CN)
Openalex Percentile: Top 100%
CRISPR and Genetic Engineering
DOISourceOpenAlex
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CRISPR-mediated WNK4 point mutation aggravates tumor progression and weakens chemotherapy sensitivity in gastric cancer. — Xiao‐Bing Gao, Xinting Lv, et al. · PubMed (2025) | TGRS Research Map | TGRS