Ganglion Cell Complex Thickness and Visual Function in Chronic Leber Hereditary Optic Neuropathy
The corrected GCC thickness showed correlation with visual function in chronic LHON subjects. The frequently occurring segmentation errors in OCT measurements related to chronic LHON can potentially be misleading in monitoring of disease progression and in evaluating the treatment effects. Precise measurements of GCC could serve as a sensitive tool to monitor structural changes in LHON. We therefore emphasize the importance of careful evaluation of the accuracy of OCT segmentation.
Authors
- Martin Engvall (ORCID: https://orcid.org/0000-0002-8339-3545)
- Pete A. Williams (ORCID: https://orcid.org/0000-0001-6194-8397)
- Maria Nilsson (ORCID: https://orcid.org/0000-0001-8416-4819)
- Abinaya Priya Venkataraman (ORCID: https://orcid.org/0000-0002-2155-7030)
- Johan Hedström
Institutions
- Karolinska Institutet (SE)
- S:t Eriks Ögonsjukhus (SE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-04
- DOI
- https://doi.org/10.1167/iovs.65.12.4
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Vetenskapsrådet
- S:t Eriks Ögonforskningsstiftelse