Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma
Thus, aberration of oral microbiota and intratumoral colonization of specific oral bacterium such as S. mutans may increase the production of onco-metabolites, exacerbate the oral mucosal carcinogenesis, reprogram a highly immunosuppressive TME, and promote OSCC, highlighting the potential of interfering with oral microbiota and microbial metabolism for OSCC preventions and therapeutics. Video Abstract.
Authors
- Guibo Li (ORCID: https://orcid.org/0000-0002-6141-4931)
- Gucheng Zeng (ORCID: https://orcid.org/0000-0002-2665-2854)
- Zixu Chen (ORCID: https://orcid.org/0000-0002-7305-9711)
- Yi Yang (ORCID: https://orcid.org/0000-0002-2519-5217)
- Lei Wang (ORCID: https://orcid.org/0000-0002-1069-7644)
- Qinchao Hu (ORCID: https://orcid.org/0000-0002-4969-0589)
- Tong Wu (ORCID: https://orcid.org/0000-0001-7455-9083)
- Zhi‐Ying Wu (ORCID: https://orcid.org/0000-0003-2106-572X)
- Bin Cheng (ORCID: https://orcid.org/0000-0002-8276-6653)
- Zixuan Hu (ORCID: https://orcid.org/0000-0002-0752-3811)
- Huan Li (ORCID: https://orcid.org/0000-0001-5125-069X)
- Rui Zhou (ORCID: https://orcid.org/0000-0002-8250-9446)
- Cuijuan Zhang (ORCID: https://orcid.org/0000-0003-4046-7687)
- Qiao Su
- Yongjie Cai (ORCID: https://orcid.org/0000-0003-2119-4134)
- Jiaying Zhou (ORCID: https://orcid.org/0000-0003-1921-7392)
- Kai Su (ORCID: https://orcid.org/0000-0002-2440-4099)
- Zhiyi Zhang (ORCID: https://orcid.org/0000-0001-8345-6588)
- Tao Lin
- Lingchan Zeng
Institutions
- BGI Group (China) (CN)
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- Botswana Geoscience Institute (BW)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
- Education Department of Jiangxi Province (CN)
- Sun Yat-sen University Cancer Center (CN)
- Nanchang Center for Disease Control and Prevention (CN)
- BGI Research (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2024-10-05
- DOI
- https://doi.org/10.1186/s40168-024-01907-9
- Citations
- 39
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 9.12